Antisense lncRNA Transcription Drives Stochastic Protocadherin α Promoter Choice

L1 Antisense Promoter Drives Tissue-Specific Transcription of Human Genes

Transcription of transposable elements interspersed in the genome is controlled by complex interactions between their regulatory elements and host factors. However, the same regulatory elements may be occasionally used for the transcription of host genes. One such example is the human L1 retrotransposon, which contains an antisense promoter (ASP) driving transcription into adjacent genes yieldi...

Genome-wide antisense transcription drives mRNA processing in bacteria.

RNA deep sequencing technologies are revealing unexpected levels of complexity in bacterial transcriptomes with the discovery of abundant noncoding RNAs, antisense RNAs, long 5' and 3' untranslated regions, and alternative operon structures. Here, by applying deep RNA sequencing to both the long and short RNA fractions (<50 nucleotides) obtained from the major human pathogen Staphylococcus aure...

CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice.

The closely linked human protocadherin (Pcdh) α, β, and γ gene clusters encode 53 distinct protein isoforms, which are expressed in a combinatorial manner to generate enormous diversity on the surface of individual neurons. This diversity is a consequence of stochastic promoter choice and alternative pre-mRNA processing. Here, we show that Pcdhα promoter choice is achieved by DNA looping betwee...

بیان LncRNA HOX transcript antisense RNA در بیماران تازه تشخیص داده شده لوسمی لنفوبلاستیک حاد

چکیده سابقه و هدف لوسمی حاد لنفوبلاستی، شایع‌ترین بدخیمی دوران کودکی می‌باشد. سالانه در کل دنیا به ازای هر 100 هزار نفر،1 تا 7/4 نفر به این بیماری مبتلا می‌شوند. Long non-coding RNA ها (lncRNAs)، گروهی از RNAهای غیرکدشونده هستند که در فرآیندهای زیستی از جمله تغییرات اپی‌ژنتیکی، کنترل رونویسی و ترجمه نقش دارند. استفاده از lncRNA های اختصاصی خونی و شناسایی عملکرد آن‌ها می‌تواند در شناخت بیشتر پا...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor